microRNAs: Master Regulators as Potential Therapeutics in Cancer

被引：235

作者：

Garofalo, Michela ^{[1
]}

Croce, Carlo M.

机构：

[1] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 51, 2011 | 2011年 / 51卷

关键词：

oncomiRs; tumor suppressor microRNAs; miRNA as drug; TUMOR-SUPPRESSOR MICRORNA; HUMAN LUNG CANCERS; CELL-CYCLE; SMALL RNAS; ANTISENSE INHIBITION; TRAIL RESISTANCE; DOWN-REGULATION; IN-VIVO; EXPRESSION; GENE;

D O I：

10.1146/annurev-pharmtox-010510-100517

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

It has been demonstrated that all the known processes involved in cancer, including apoptosis, proliferation, survival, and metastasis, are regulated by small regulatory noncoding RNAs consisting of approximately 19-25 nucleotides; these are named microRNAs (miRNAs). Both loss and gain of miRNA function contribute to cancer development through the upregulation and silencing, respectively, of different target genes. Experimental evidence indicates that the use of miRNA mimics or anti-microRNAs may represent a powerful therapeutic strategy to interfere with key molecular pathways involved in cancer. This review provides insights about how microRNAs act as oncogenes and tumor suppressor genes and how these findings, along with our increasing understanding of miRNA regulation, can be applied to optimize recent miRNA-based technologies and make them suitable for clinical applications.

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收藏

页码：25 / 43

页数：19

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