Stress-induced expression of transcriptional repressor ICER in the adrenal gland

被引:22
作者
Della Fazia, MA [1 ]
Servillo, G [1 ]
Foulkes, NS [1 ]
Sassone-Corsi, P [1 ]
机构
[1] Univ Louis Pasteur Strasbourg 1, Inst Genet & Biol Mol & Cellulaire, CNRS, INSERM, F-67404 Illkirch, France
关键词
inducible cAMP early repressor; cAMP-responsive element modulator; adrenocorticotropin hormone; adrenal gland; surgery; stress;
D O I
10.1016/S0014-5793(98)00944-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Second messenger cyclic AMP plays a central role in signalling within the hypothalamo-pituitary-adrenal (HPA) axis. Changes in gene expression are central to long-term adaptations made in response to stress in the adrenal gland. Here we demonstrate that expression of the cAMP inducible transcriptional repressor, ICER (Inducible cAMP Early Repressor), is rapidly and powerfully induced in response to surgical stress in the rat adrenal gland. Hypophysectomisation blocks stress-induced ICER expression. Finally we demonstrate that injection of the pituitary hormone ACTH (Adrenocorticotropin Hormone) induces robust ICER expression in the adrenal cortex. Thus, induction of the transcriptional repressor ICER is coupled to the HPA axis response to stress. (C) 1998 Federation of European Biochemical Societies.
引用
收藏
页码:33 / 36
页数:4
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