Effect of interferon-α on experimental septal fibrosis of the liver -: Study with a new model

被引：11

作者：

de Souza, MM

Paraná, R

Trepo, C

Barbosa, AA

Oliveira, I

Andrade, ZA

机构：

[1] Fiocruz MS, Ctr Pesquisas Goncalo Moniz, BR-40295001 Salvador, BA, Brazil

[2] Univ Fed Bahia, Fac Med, Salvador, BA, Brazil

[3] INSERM U271, Lyon, France

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2001年 / 96卷 / 03期

关键词：

interferon-alpha; hepatic fibrosis; Capillaria hepatica;

D O I：

10.1590/S0074-02762001000300010

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Interferon-alpha is used in antiviral therapy in humans, mainly for viral hepatitis B and C. An anti-fibrotic effect of interferon has been postulated even in the absence of anti-viral response, which suggests that interferon directly inhibits fibrogenesis. Rats infected with the helminth Capillaria hepatica regularly develop diffuse septal fibrosis of the liver, which terminates in cirrhosis 40 days after inoculation. The aim of this study was to test the anti-fibrotic effect of interferon in this experimental model. Evaluation of fibrosis was made by three separate methods: semi-quantitative histology, computerized morphometry and hydroxyproline measurements. Treatment with interferon-alpha proved to inhibit the development of fibrosis in this model especially when doses of 500,000 and 800,000 IU were used for 60 days. Besides confirming the anti-fibrotic potential of interferon-alpha on a non-viral new experimental model of hepatic fibrosis, a clear-cut dose-dependent effect was observed.

引用

页码：343 / 348

页数：6

共 20 条

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