Cell biology - Shape-shifting protein channel

被引：5

作者：

Benach, J ^{[1
]}

Hunt, JF ^{[1
]}

机构：

[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

NATURE | 2004年 / 427卷 / 6969期

关键词：

D O I：

10.1038/427024a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Newly made proteins are moved across cellular membranes through a protein channel. The crystal structure of this channel is now revealed and confirms expectations that it must change shape to allow proteins to pass.

引用

页码：24 / 26

页数：3

共 15 条

[1] Architecture of the protein-conducting channel associated with the translating 80S ribosome [J].

Beckmann, R ;

Spahn, CMT ;

Eswar, N ;

Helmers, J ;

Penczek, PA ;

Sali, A ;

Frank, J ;

Blobel, G .

CELL, 2001, 107 (03) :361-372

[2] INTRACELLULAR PROTEIN TOPOGENESIS [J].

BLOBEL, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (03) :1496-1500

[3] TRANSFER OF PROTEINS ACROSS MEMBRANES .1. PRESENCE OF PROTEOLYTICALLY PROCESSED AND UNPROCESSED NASCENT IMMUNOGLOBULIN LIGHT-CHAINS ON MEMBRANE-BOUND RIBOSOMES OF MURINE MYELOMA [J].

BLOBEL, G ;

DOBBERSTEIN, B .

JOURNAL OF CELL BIOLOGY, 1975, 67 (03) :835-851

[4] The bacterial translocase: a dynamic protein channel complex [J].

de Keyzer, J ;

van der Does, C ;

Driessen, AJM .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2003, 60 (10) :2034-2052

[5] The cotranslational integration of membrane proteins into the phospholipid bilayer is a multistep process [J].

Do, H ;

Falcone, D ;

Lin, JL ;

Andrews, DW ;

Johnson, AE .

CELL, 1996, 85 (03) :369-378

[6] Binding, activation and dissociation of the dimeric SecA ATPase at the dimeric SecYEG translocase [J].

Duong, F .

EMBO JOURNAL, 2003, 22 (17) :4375-4384

[7] BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation [J].

Hamman, BD ;

Hendershot, LM ;

Johnson, AE .

CELL, 1998, 92 (06) :747-758

[8] The aqueous pore through the translocon has a diameter of 40-60 angstrom during cotranslational protein translocation at the ER membrane [J].

Hamman, BD ;

Chen, JC ;

Johnson, EE ;

Johnson, AE .

CELL, 1997, 89 (04) :535-544

[9] Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA [J].

Hunt, JF ;

Weinkauf, S ;

Henry, L ;

Fak, JJ ;

McNicholas, P ;

Oliver, DB ;

Deisenhofer, J .

SCIENCE, 2002, 297 (5589) :2018-2026

[10]

Rapoport TA, 1996, ANNU REV BIOCHEM, V65, P271

← 1 2 →