Proteasome inhibitors: from research tools to drug candidates

被引：971

作者：

Kisselev, AF ^{[1
]}

Goldberg, AL ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

CHEMISTRY & BIOLOGY | 2001年 / 8卷 / 08期

关键词：

proteasome inhibitor; ubiquitin-proteasome pathway; drug candidate;

D O I：

10.1016/S1074-5521(01)00056-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 26S proteasome is a 2.4 MDa multifunctional ATP-dependent proteolytic complex, which degrades the majority of cellular polypeptides by an unusual enzyme mechanism. Several groups of proteasome inhibitors have been developed and are now widely used as research tools to study the role of the ubiquitin-proteasome pathway in various cellular processes, and two inhibitors are now in clinical trials for treatment of multiple cancers and stroke. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：739 / 758

页数：20

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