Direct Access to N-Alkylsulfoximines from Sulfides by a Sequential Imidation/Oxidation Procedure

被引：25

作者：

Dannenberg, Carl Albrecht ^{[1
]}

Bizet, Vincent ^{[1
]}

Bolm, Carsten ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 13期

关键词：

sulfoximine; imidation; oxidation; synthetic method; sulfide; SULFOXIMINES SYNTHESES; SYNTHETIC APPLICATIONS; MEDICINAL CHEMISTRY; NITRENE TRANSFER; ALKYLATION; MECHANISM; SULFILIMINES; SULFIMIDES; INHIBITOR; NITROGEN;

D O I：

10.1055/s-0034-1380536

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

Synthetically relevant N-alkyl-substituted sulfoximines are directly prepared from sulfides by an unprecedented one-pot imidation/oxidation sequence. In situ generated N-bromoalkylamines serve as readily accessible imidating agents leading to N-alkylsulfiliminium bromides that are subsequently oxidized providing the corresponding N-alkylsulfoximines. In this manner, gram quantities of the products can be obtained in a short period of time avoiding the use of toxic and cumbersome to handle alkylating reagents.

引用

页码：1951 / 1959

页数：9

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