Rosiglitazone Ameliorates Diabetic Nephropathy by Reducing the Expression of Chemerin and ChemR23 in the Kidney of Streptozotocin-Induced Diabetic Rats

被引：54

作者：

Hu, Wenchao ^{[2
]}

Yu, Qian ^{[1
]}

Zhang, Jie ^{[1
]}

Liu, Demin ^{[1
]}

机构：

[1] Tianjin Med Univ, Metab Dis Hosp, Dept Lab, Tianjin 300070, Peoples R China

[2] Tianjin Med Univ, Gen Hosp, Dept Metab, Tianjin, Peoples R China

来源：

INFLAMMATION | 2012年 / 35卷 / 04期

关键词：

chemerin; ChemR23; diabetic nephropathy; rosiglitazone; pioglitazone; inflammation; GROWTH-FACTOR-BETA; METABOLIC SYNDROME; MARKERS; ADIPOGENESIS; INFLAMMATION; ADIPONECTIN; IMPROVEMENT; DECREASES; ADIPOKINE; DISEASE;

D O I：

10.1007/s10753-012-9440-y

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. This study aims to determine whether rosiglitazone and pioglitazone ameliorate renal function through an effect on the expression of chemerin and ChemR23 in streptozotocin-induced diabetic rats. The rats were randomized to control, diabetic, rosiglitazone-, and pioglitazone-treated groups. The expression level of chemerin and ChemR23 in the renal tissues was significantly elevated in the diabetic group compared with the control group. Rosiglitazone inhibited the overexpression of chemerin and ChemR23, while pioglitazone inhibited the overexpression of ChemR23 in the kidney of diabetic rats. In addition, chemerin expression level was positively correlated with transforming growth factor-beta 1, connective tissue growth factor, tumor necrosis factor-alpha, and intracellular cell adhesion molecule-1 expression in diabetic rats. Rosiglitazone ameliorates diabetic nephropathy by reducing the expression of chemerin and ChemR23 in diabetic rats.

引用

页码：1287 / 1293

页数：7

共 30 条

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