Tolerance of granulocyte donors towards granulocyte colony-stimulating factor stimulation and of patients towards granulocyte transfusions: results of a multicentre study

被引：31

作者：

Bux, J

Cassens, U

Dielschneider, T

Duchscherer, M

Edel, E

Eichler, H

Haas, C

Moog, R

Peschke, H

Peters, C

Ryzenkov, I

Schlenke, P

Ullrich, H

Wiesneth, M

机构：

[1] Univ Giessen, Inst Clin Immunol & Transfus Med, Dept Transfus Med, D-35385 Giessen, Germany

[2] Univ Munster, Dept Transfus Med, D-4400 Munster, Germany

[3] Univ Hamburg, Dept Transfus Med, Hamburg, Germany

[4] Univ Frankfurt, Dept Transfus Med, D-6000 Frankfurt, Germany

[5] Univ Leipzig, Dept Transfus Med, Leipzig, Germany

[6] Univ Mannheim, Dept Transfus Med, Mannheim, Germany

[7] Univ Marburg, Dept Transfus Med, Marburg, Germany

[8] Univ Essen Gesamthsch, Dept Transfus Med, Essen, Germany

[9] Univ Halle Wittenberg, Dept Transfus Med, Halle An Der Saale, Germany

[10] St Anna Kinderspital Wien, Vienna, Austria

[11] Univ Lubeck, Dept Transfus Med, Lubeck, Germany

[12] Univ Regensburg, Dept Transfus Med, D-8400 Regensburg, Germany

[13] Univ Ulm, Dept Transfus Med, D-7900 Ulm, Germany

来源：

VOX SANGUINIS | 2003年 / 85卷 / 04期

关键词：

granulocyte transfusion; G-G'SF; granulocyte apheresis;

D O I：

10.1111/j.0042-9007.2003.00373.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Data of 507 granulocyte donations from 183 donors were evaluated. No severe granulocyte colony-stimulating factor (G-CSF)-related side-effects were observed. Three donors complained of severe itching following infusion of hydroxyethyl starch (HES). A high proportion (85%) of the donors stated that they would donate granulocytes again. The mean granulocyte yield was 4.3 x 10(10). High-molecular-weight HES resulted in a significantly higher yield compared with low-molecular-weight HES. Mild, but no severe, adverse transfusion reactions were observed in 16% of the recipients. A leucocyte alloimmunization rate of 24% was found. G-CSF stimulation and transfusion of G-CSF-mobilized granulocytes were well tolerated by donors and recipients, respectively

引用

页码：322 / 325

页数：4

共 13 条

[1] Effect of leukocyte compatibility on neutrophil increment after transfusion of granulocyte colony-stimulating factor-mobilized prophylactic granulocyte transfusions and on clinical outcomes after stem cell transplantation [J].