The IGF-I receptor protects tumor cells from apoptosis induced by high concentrations of serum

被引：22

作者：

Valentinis, B ^{[1
]}

Baserga, R ^{[1
]}

机构：

[1] THOMAS JEFFERSON UNIV,KIMMEL CANC CTR,PHILADELPHIA,PA 19107

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 224卷 / 02期

关键词：

D O I：

10.1006/bbrc.1996.1034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

High concentrations of fetal bovine serum (FBS) induce apoptosis of cells in culture. A decrease in the number of insulin-like growth factor I receptors (IGF-IR) sensitizes the cells to serum-induced apoptosis. Autophosphorylation of the IGF-IR is not affected by high serum, These results may explain why the targeting of the IGF-IR renders tumor cells much more sensitive to apoptosis in vivo than in vitro. (C) 1996 Academic Press, Inc.

引用

页码：362 / 368

页数：7

共 25 条

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