Preoperative vincristine for an inoperable choroid plexus papilloma: a case discussion and review of the literature Case report

被引：10

作者：

Addo, Nli K. ^{[4
]}

Kamaly-Asl, Ian D. ^{[1
]}

Josan, Vivek A. ^{[1
]}

Kelsey, Anna M. ^{[2
]}

Estlin, Edward J. ^{[3
]}

机构：

[1] Royal Manchester Childrens Hosp, Dept Pediat Neurosurg, Manchester M13 9WL, Lancs, England

[2] Royal Manchester Childrens Hosp, Dept Pediat Histopathol, Manchester M13 9WL, Lancs, England

[3] Royal Manchester Childrens Hosp, Dept Pediat Oncol, Manchester M13 9WL, Lancs, England

[4] Univ Manchester, Sch Med, Manchester, Lancs, England

来源：

JOURNAL OF NEUROSURGERY-PEDIATRICS | 2011年 / 8卷 / 02期

关键词：

choroid plexus papilloma; vincristine; embolization; intraoperative hemorrhage; neoadjuvant chemotherapy; oncology; 20 YEARS EXPERIENCE; CHILDREN; TUMORS; 3RD-VENTRICLE; EMBOLIZATION; MANAGEMENT; CHILDHOOD; SURGERY; INFANT; AGENTS;

D O I：

10.3171/2011.5.PEDS1187

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors report the case of a 14-month-old boy with a large right intraventricular choroid plexus papilloma (CPP) for which the first attempt at resection resulted in life-threatening intraoperative hemorrhage. The tumor was unsuitable for embolization, and neoadjuvant ifosfamide, carboplatin, etoposide (ICE) chemotherapy had no effect on tumor size. However, chemotherapy with vincristine, although not impacting on CT perfusion parameters, resulted in a significant decrease in tumor size, enabling complete resection with manageable blood loss. The mechanism underlying the effect of vincristine in this case is uncertain, but it is a treatment strategy that warrants further evaluation for the treatment of CPPs that are not amenable to embolization. (DOI: 10.3171/2011.5.PEDS1187)

引用

页码：149 / 153

页数：5

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