Effect of a nitric oxide donor on nitroxergic nerve fibers in the rat dura mater

被引：31

作者：

Knyihár-Csillik, E ^{[1
]}

Vécsei, L ^{[1
]}

机构：

[1] Albert Szent Gyorgyi Med Univ Sch, Dept Neurol, H-6701 Szeged, Hungary

来源：

NEUROSCIENCE LETTERS | 1999年 / 260卷 / 02期

关键词：

nitric oxide synthase; immunohistochemistry; dura mater; nitroglycerine; migraine headache;

D O I：

10.1016/S0304-3940(98)00949-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nitroglycerine, given subcutaneously to rats (10 mg/kg body weight) induces increased beading of nitric oxide synthase immunoreactive (NOS-IR) nerve fibers in the supratentorial cerebral dura mater, and an apparent increase in the number of NOS-IR nerve fibers in the dural areas supplied by the anterior and middle meningeal arteries, and the sinus sagittalis superior. Structural alterations of nitroxergic axons innervating blood vessels of the dura mater support the idea that nitric oxide is involved in the induction of headache also by a primary peripheral action, a well-known side effect of coronary dilator agents. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：97 / 100

页数：4

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