Evaluation of acute hematologic and long-term pulmonary toxicities of radioimmunotherapy of Cryptococcus neoformans infection in murine models

被引：27

作者：

Dadachova, E

Bryan, RA

Frenkel, A

Zhang, T

Apostolidis, C

Nosanchuk, JS

Nosanchuk, JD

Casadevall, A

机构：

[1] Albert Einstein Coll Med, Dept Nucl Med, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

[4] Cornell Univ, Ithaca, NY USA

[5] Inst Transuranium Elements, Heidelberg, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 03期

关键词：

D O I：

10.1128/AAC.48.3.1004-1006.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We evaluated acute hematological and long-term pulmonary toxicity of radioimmunotherapy in murine models of Cryptococcus neoformans infection. Activities up to 250 muCi were well tolerated by healthy A/JCr mice for Bi-213-18B7 and Re-188-18B7 monoclonal antibodies. In infected mice, doses up to 150 muCi produced only transient toxicity. The lungs of treated mice had no evidence of radiation fibrosis.

引用

页码：1004 / 1006

页数：3

共 10 条

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