N-[O-1,2,3-benzotriazin-4(3H)one-yl]-3,(2-pyridyldithio)propionate a more reactive alternative to SPDP

被引：10

作者：

Janout, V

Lanier, M

Regen, SL ^{[1
]}

机构：

[1] Lehigh Univ, Dept Chem, Bethlehem, PA 18015 USA

[2] Lehigh Univ, Zettlemoyer Ctr Surface Studies, Bethlehem, PA 18015 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(98)02593-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-[O-1,2,3-Benzotriazin-4(3H)one-yl]-3-(2-pyridyldithio)propionate [BPDP] has been synthesized and found to react with secondary amines to give high yields of acylated product. In sharp contrast, the widely used heterobifunctional coupling reagent, N-[O-succinimdyl]-3-(2-pyridyldithio) propionate [SPDP] afforded low to negligible yields of product. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1107 / 1108

页数：2