An in vitro study on the toxic effects of nonylphenols (NP) in mitochondria

被引：37

作者：

Bragadin, M

Perin, G

Iero, A

Manente, S

Rizzoli, V

Scutari, G

机构：

[1] Univ Venice, Dipartimento Sci Ambientali, I-30123 Venice, Italy

[2] Univ Padua, Dipartimento Chim Biol, I-35121 Padua, Italy

来源：

CHEMOSPHERE | 1999年 / 38卷 / 09期

关键词：

D O I：

10.1016/S0045-6535(98)00412-3

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This paper is focused on alkylphenols, compounds which are formed by the biodegradation of polyethoxilatedalkylphenols detergents. Our experiments show that alkylphenols act not only as detergents, but also as uncouplers of the oxidative phosphorylation. This effect, can be observed at very low doses, thus suggesting that the preferential target of nonylphenols in living organisms are mitochondria. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1997 / 2001

页数：5

共 11 条

[1] PERSISTENT ORGANIC-CHEMICALS IN SEWAGE EFFLUENTS .3. DETERMINATIONS OF NONYLPHENOXY CARBOXYLIC-ACIDS BY HIGH-RESOLUTION GAS-CHROMATOGRAPHY MASS-SPECTROMETRY AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
AHEL, M
CONRAD, T
GIGER, W
[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1987, 21 (07) : 697 - 703
[2] MAMMALIAN MITOCHONDRIA AS INVITRO MONITORS OF WATER-QUALITY
BLONDIN, GA
KNOBELOCH, LM
READ, HW
HARKIN, JM
[J]. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1987, 38 (03) : 467 - 474
[3] The accumulation in lysosomes of the anionic detergent linear alkylbenzene sulfonate
Bragadin, M
Perin, G
Raccanelli, S
Manente, S
[J]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 1996, 15 (10) : 1749 - 1751
[4] BRAGADIN M, 1994, ARCH ENVIRON CON TOX, V27, P410, DOI 10.1007/BF00213179
[5] Bragadin M, 1996, ARCH ENVIRON CON TOX, V30, P280
[6] ESTABROOK RW, 1967, METHOD ENZYMOL, V10, P47
[7] FELL B, 1991, TENSIDE SURFACT DET, V28, P385
[8] 4-NONYLPHENOL IN SEWAGE-SLUDGE - ACCUMULATION OF TOXIC METABOLITES FROM NONIONIC SURFACTANTS
GIGER, W
BRUNNER, PH
SCHAFFNER, C
[J]. SCIENCE, 1984, 225 (4662) : 623 - 625
[9] BEHAVIOR OF ALKYLPHENOL POLYETHOXYLATE SURFACTANTS AND OF NITRILOTRIACETATE IN SEWAGE-TREATMENT
GIGER, W
AHEL, M
KOCH, M
LAUBSCHER, HU
SCHAFFNER, C
SCHNEIDER, J
[J]. WATER SCIENCE AND TECHNOLOGY, 1987, 19 (3-4) : 449 - 460
[10] MITOCHONDRIAL RESPONSE TO CHLOROPHENOLS AS A SHORT-TERM TOXICITY ASSAY
SHANNON, RD
BOARDMAN, GD
DIETRICH, AM
BEVAN, DR
[J]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 1991, 10 (01) : 57 - 66

← 1 2 →