Premetastatic niche: ready for new therapeutic interventions?

被引：28

作者：

Zoccoli, Alice ^{[1
]}

Iuliani, Michele ^{[1
]}

Pantano, Francesco ^{[1
]}

Imperatori, Marco ^{[1
]}

Intagliata, Salvatore ^{[1
]}

Vincenzi, Bruno ^{[1
]}

Marchetti, Paolo ^{[1
,2
]}

Papapietro, Nicola ^{[4
]}

Denaro, Vincenzo ^{[4
]}

Tonini, Giuseppe ^{[1
]}

Santini, Daniele ^{[1
,3
]}

机构：

[1] Campus Biomed Univ, Dept Med Oncol, Rome, Italy

[2] St Andrea Hosp, Dept Med Oncol, Rome, Italy

[3] Univ Campus Biomed, I-00128 Rome, Italy

[4] Campus Biomed Univ, Dept Orthopaed & Trauma Surg, Rome, Italy

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2012年 / 16卷

关键词：

bone marrow derived cells (BMDC); cancer stem-like cells (CSC); chemokine; integrin; premetastatic niche RANK/RANKL; BREAST-CANCER METASTASIS; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-ASSOCIATED MACROPHAGES; M1 TRANSCRIPTION FACTOR; NF-KAPPA-B; BONE METASTASIS; LYSYL OXIDASE; OSTEOCLAST PRECURSORS; MESSENGER-RNA; CELL ADHESION;

D O I：

10.1517/14728222.2012.656092

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Introduction: Bone marrow-derived cells (BMDC) localize in premetastatic niche through chemokines and integrins signals and establish clusters that precede the arrival of even single metastatic tumor cell at distant site. CSCs demonstrate an increased metastatic propensity and would seem likely candidates for the acquisition of migratory capabilities and propagation of heterogeneous tumor cell populations to different target organs. Sonic Hedgehog (SHH), FOXM1 and Notch pathways and signaling molecules such as integrin and chemokine could dictate their fate. Areas covered: In this review, the molecular mechanisms of premetastatic niche onset are summarized. Expert opinion: Premetastatic niche is defined as a fertile microenvironment that forms in metastatic target organ and facilitates the invasion, survival and/or proliferation of metastatic tumor cells, providing a novel mechanism for the promotion of metastasis. Drugs targeting premetastatic niche could represent a new promising therapeutic approach in the treatment of bone metastases.

引用

页码：S119 / S129

页数：11

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