The role of inositol trisphosphate-induced Ca2+ release from IP3-receptor in the rat suprachiasmatic nucleus on circadian entrainment mechanism

被引:42
作者
Hamada, T
Liou, SY
Fukushima, T
Maruyama, T
Watanabe, S
Mikoshiba, K
Ishida, N
机构
[1] MITI, Agcy Ind Sci & Technol, Ishida Grp Clock Gene, Natl Inst Biosci & Human Technol, Tsukuba, Ibaraki 3058566, Japan
[2] Nippon Glaxo Ltd, Tsukuba Res Labs, Pharmacol, Tsukuba, Ibaraki 30042, Japan
[3] Kyushu Univ 62, Fac Pharmaceut Sci, Dept Pharmacol, Fukuoka 8128582, Japan
[4] Univ Tokyo, Inst Med Sci, Dept Mol Microbiol, Minato Ku, Tokyo 108, Japan
关键词
inositol trisphosphate receptor; Ca2+; rat suprachiasmatic nucleus; 2-amino-ethoxy diphenylbolate; suprachiasmatic nucleus field potential; suprachiasmatic nucleus firing rhythm; suprachiasmatic nucleus slice culture;
D O I
10.1016/S0304-3940(99)00111-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Synchronization between the environmental lighting cycle and the circadian clock in the suprachiasmatic nucleus (SCN) is correlated with Ca2+ increase. The mechanism underlying the increase of Ca2+ and its relation to clock resetting are unknown. To address these issues, we examined the possibility whether inositol 1,4,5-trisphosphate receptor (IP3-R), which regulate intracellular Ca2+, was involved in the circadian rhythm component of the rat SCN. A novel IP3-induced Ca2+ release modulator, 2-amino-ethoxy diphenylborate (2APB), blocked optic nerve stimulation-induced neuronal field potentials in the SCN. Furthermore, glutamate-induced phase delay of the circadian firing pattern in the SCN was also blocked completely by 2APB in vitro. Together, these data suggest the possibility that IP3-induced Ca2+ release through IP3-R plays a role in the entrainment of the mammalian circadian clock, the SCN. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:125 / 128
页数:4
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