Grandisine A and B, novel indolizidine alkaloids with human δ-opioid receptor binding affinity from the leaves of the Australian rainforest tree Elaeocarpus grandis

被引：45

作者：

Carroll, AR ^{[1
]}

Arumugan, G

Quinn, RJ

Redburn, J

Guymer, G

Grimshaw, P

机构：

[1] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

[2] Queensland Herbarium, Brisbane Bot Gardens, Brisbane, Qld 4006, Australia

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 05期

关键词：

D O I：

10.1021/jo048525n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel indolizidine alkaloids, grandisine A (1) and B (2), and the known alkaloid (-) isoelaeocarpiline (3) were isolated from the leaves of Elaeocarpus grandis and their structures determined by 1D and 2D NMR spectroscopy. The compounds showed affinity for the human delta-opioid receptor. Grandisine A contains a unique tetracyclic skeleton, while grandisine B possesses the unique combination of isoquinuclidinone and indolizidine groups in one molecule.

引用

页码：1889 / 1892

页数：4

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