Telomeres, the nucleolus and aging

被引：54

作者：

Johnson, FB ^{[1
]}

Marciniak, RA ^{[1
]}

Guarente, L ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 03期

关键词：

D O I：

10.1016/S0955-0674(98)80008-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reactivation of telomerase in cultured human cells extends their replicative life span beyond the Hayflick limit. How telomere shortening triggers cell senescence and whether it contributes to aging in vivo are under investigation. Studies in yeast have revealed another site critical to cellular aging: the nucleolus. The accumulation of ribosomal DNA circles is a cause of aging in this organism. The possible relevance of this mechanism to human aging is also being considered.

引用

页码：332 / 338

页数：7

共 71 条

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