CDI-restricted T cells and resistance to polysaccharide-encapsulated bacteria

被引：28

作者：

Fairhurst, RM ^{[1
]}

Wang, CX

Sieling, PA

Modlin, RL

Braun, J

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Sch Med, Dept Microbiol & Immunol, Los Angeles, CA 90095 USA

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 06期

关键词：

D O I：

10.1016/S0167-5699(97)01235-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD1 has been distinguished from conventional antigen-presenting molecules by its ability to present mycobacterial lipoglycans. Here, Rick Fairhurst and colleagues postulate that the hydrophobic groove of CD1 binds palmitic acid, displaying diverse, covalently-attached carbohydrates to T cells. Such T cells may constitute a previously unappreciated subset that helps B cells mount an antibody response to polysaccharide antigens.

引用

页码：257 / 259

页数：3

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