Computational protein engineering

被引:45
作者
Hellinga, HW [1 ]
机构
[1] Duke Univ, Med Ctr, Dept Biochem, Durham, NC 27710 USA
关键词
D O I
10.1038/776
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent advances in automated protein design algorithms are leading a resurgence in structure-based design approaches for protein engineering.
引用
收藏
页码:525 / 527
页数:3
相关论文
共 37 条
[1]   ENGINEERED METAL-BINDING PROTEINS - PURIFICATION TO PROTEIN FOLDING [J].
ARNOLD, FH ;
HAYMORE, BL .
SCIENCE, 1991, 252 (5014) :1796-1797
[2]   Design by directed evolution [J].
Arnold, FH .
ACCOUNTS OF CHEMICAL RESEARCH, 1998, 31 (03) :125-131
[3]   Construction of a novel redox protein by rational design: Conversion of a disulfide bridge into a mononuclear iron-sulfur center [J].
Benson, DE ;
Wisz, MS ;
Liu, WT ;
Hellinga, HW .
BIOCHEMISTRY, 1998, 37 (20) :7070-7076
[4]   X-ray structures of a designed binding site in trypsin show metal-dependent geometry [J].
Brinen, LS ;
Willett, WS ;
Craik, CS ;
Fletterick, RJ .
BIOCHEMISTRY, 1996, 35 (19) :5999-6009
[5]   IDENTIFICATION OF THE MOLECULAR TRIGGER FOR ALLOSTERIC ACTIVATION IN GLYCOGEN-PHOSPHORYLASE [J].
BROWNER, MF ;
HACKOS, D ;
FLETTERICK, R .
NATURE STRUCTURAL BIOLOGY, 1994, 1 (05) :327-333
[6]   PROTEIN DESIGN - A HIERARCHICAL APPROACH [J].
BRYSON, JW ;
BETZ, SF ;
LU, HS ;
SUICH, DJ ;
ZHOU, HXX ;
ONEIL, KT ;
DEGRADO, WF .
SCIENCE, 1995, 270 (5238) :935-941
[7]  
CLARKE ND, 1995, NAT STRUCT BIOL, V2, P256
[8]  
CLDREN CD, 1997, P NTL ACAD SCI US, V94, P6635
[9]   On the failure of de novo-designed peptides as biocatalysts [J].
Corey, MJ ;
Corey, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (21) :11428-11434
[10]   Protein design automation [J].
Dahiyat, BI ;
Mayo, SL .
PROTEIN SCIENCE, 1996, 5 (05) :895-903