Daily restricted feeding rescues a rhythm of Period2 expression in the arrhythmic suprachiasmatic nucleus

被引：71

作者：

Lamont, EW ^{[1
]}

Diaz, LR ^{[1
]}

Barry-Shaw, J ^{[1
]}

Stewart, J ^{[1
]}

Amir, S ^{[1
]}

机构：

[1] Concordia Univ, Dept Psychol, Ctr Studies Behav Neurobiol, Montreal, PQ H4B 1R6, Canada

来源：

NEUROSCIENCE | 2005年 / 132卷 / 02期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

D O I：

10.1016/j.neuroscience.2005.01.029

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Second only to light, daily restricted feeding schedules can entrain circadian rhythms in mammals [Neurosci Biobehav Rev 4 (1980) 119; J Biol Rhythms 17 (2002) 284]. Contrary to light, however, such feeding schedules have been found not to affect the master circadian clock in the suprachiasmatic nucleus (SCN) [Genes Dev 14 (2000) 2950; Eur J Neurosci 13 (2001) 1190]. Here, we show that in rats that are arrhythmic as a consequence of prolonged housing in constant light, a daily restricted feeding schedule not only restores behavioral rhythmicity, as previously shown [Physiol Behav 53 (1993) 509], but in addition, induces a rhythm of the clock protein, Period2 in the SCN. These findings challenge the idea that the SCN is invulnerable to feeding schedules and call for a reevaluation of the role of the SCN clock in the circadian effects of such schedules. (c) 2005 Published by Elsevier Ltd on behalf of IBRO.

引用

页码：245 / 248

页数：4

共 22 条

[1] A circadian rhythm in the expression of PERIOD2 protein reveals a novel SCN-controlled oscillator in the oval nucleus of the bed nucleus of the stria terminalis [J].

Amir, S ;

Lamont, EW ;

Robinson, B ;

Stewart, J .

JOURNAL OF NEUROSCIENCE, 2004, 24 (04) :781-790

[2] Expression profiles of PER2 immunoreactivity within the shell and core regions of the rat suprachiasmatic nucleus -: Lack of photic entrainment and disruption by constant light [J].

Beaulé, C ;

Houle, LM ;

Amir, S .

JOURNAL OF MOLECULAR NEUROSCIENCE, 2003, 21 (02) :133-147

[3] FOOD AVAILABILITY AND DAILY BIOLOGICAL RHYTHMS [J].

BOULOS, Z ;

TERMAN, M .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1980, 4 (02) :119-131

[4] Entrainment of the master circadian clock by scheduled feeding [J].

Castillo, MR ;

Hochstetler, KJ ;

Tavernier, RJ ;

Greene, DM ;

Bult-Ito, A .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2004, 287 (03) :R551-R555

[5] Synchronization of the molecular clockwork by light- and food-related cues in mammals [J].

Challet, E ;

Caldelas, I ;

Graff, C ;

Pévet, P .

BIOLOGICAL CHEMISTRY, 2003, 384 (05) :711-719

[6] Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus [J].

Damiola, F ;

Le Minh, N ;

Preitner, N ;

Kornmann, B ;

Fleury-Olela, F ;

Schibler, U .

GENES & DEVELOPMENT, 2000, 14 (23) :2950-2961

[7] Sleep states alter activity of suprachiasmatic nucleus neurons [J].

Deboer, T ;

Vansteensel, MJ ;

Détári, L ;

Meijer, JH .

NATURE NEUROSCIENCE, 2003, 6 (10) :1086-1090

[8] Restricted feeding entrains liver clock without participation of the suprachiasmatic nucleus [J].

Hara, R ;

Wan, KK ;

Wakamatsu, H ;

Aida, R ;

Moriya, T ;

Akiyama, M ;

Shibata, S .

GENES TO CELLS, 2001, 6 (03) :269-278

[9] Effect of feeding on peripheral circadian rhythms and behaviour in mammals [J].

Kobayashi, H ;

Oishi, K ;

Hanai, S ;

Ishida, N .

GENES TO CELLS, 2004, 9 (09) :857-864

[10] EFFECTS OF SCHEDULED FOOD AND WATER ACCESS ON CIRCADIAN-RHYTHMS OF HAMSTERS IN CONSTANT LIGHT, DARK, AND LIGHT-DARK [J].

MISTLBERGER, RE .

PHYSIOLOGY & BEHAVIOR, 1993, 53 (03) :509-516

← 1 2 3 →