1H NMR investigation of competitive binding of sulfur-containing peptides and guanosine 5′-monophosphate to a monofunctional platinum(II) complex

被引：9

作者：

Djuran, MI ^{[1
]}

Milinkovic, SU ^{[1
]}

Bugarcic, ZD ^{[1
]}

机构：

[1] Univ Kragujevac, Fac Sci, Dept Chem, YU-34000 Kragujevac, Yugoslavia

来源：

JOURNAL OF COORDINATION CHEMISTRY | 1998年 / 44卷 / 3-4期

关键词：

platinum(II); peptide; guanosine-5 '-monophosphate; proton NMR; intermolecular displacement;

D O I：

10.1080/00958979808023081

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The competitive binding of N-acetylglycyl-D,L-methionine (AcGly-Met) and guanosine-5'-monophosphate (5'-GMP) to the monofunctional [Pt(dien)Cl](+) complex has been studied by H-1 NMR spectroscopy. Results have shown that in the initial stages of the reaction the platinum(II) complex only reacts with the methionine containing peptide, and the second step of this reaction is the very slow intermolecular displacement of the S-bound thioether ligand with the N7 atom of the guanine base of 5'-GMP. Comparative reactions of glutathione have also been investigated. The obtained results have been analyzed in relation to the antitumour activity and toxicity of platinum complexes.

引用

页码：289 / 297

页数：9

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