Inhibitory activities of quinolones against DNA gyrase of Chlamydia pneumoniae

被引：23

作者：

Ameyama, S ^{[1
]}

Shinmura, Y ^{[1
]}

Takahata, M ^{[1
]}

机构：

[1] Toyama Chem Co Ltd, Res Labs, Toyama 9308508, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 07期

关键词：

D O I：

10.1128/AAC.47.7.2327-2329.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

The gyrA and gyrB genes of Chlamydia pneumoniae TW-183 were cloned, and their proteins were purified by use of a fusion system with a maltose-binding protein. The 50% inhibitory concentrations of garenoxacin, sparfloxacin, moxifloxacin, gatifloxacin, and levofloxacin were 10.1, 47.5, 39.6, 64.2, and 156.9 mug/ml, respectively, and the MICs against C. pneumoniae TW-183 were 0.008, 0.016, 0.063, 0.125, and 0.25 mug/ml, respectively.

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收藏

页码：2327 / 2329

页数：3

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