Single-molecule covalent chemistry with spatially separated reactants

被引：96

作者：

Luchian, T

Shin, SH

Bayley, H

机构：

[1] Texas A&M Univ, Hlth Sci Ctr, Dept Med Biochem & Genet, College Stn, TX 77843 USA

[2] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 32期

关键词：

kinetics; nanoreactors; protein pores; single-molecule studies; thiols;

D O I：

10.1002/anie.200351313

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In a recent study, the reversible covalent chemistry of a simple reaction was monitored at the single-molecule level by observing the current flowing through a protein pore, which acted as a nanoreactor. Now, a multistep reaction has been observed by an improved approach, in which two of the reactants are separated by the membrane that contains the pore and diffuse into the reaction zone (see picture).

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收藏

页码：3766 / 3771

页数：6

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