Characteristics of response of oral and pharyngeal mucosa in patients receiving chemo-IMRT for head and neck cancer using hypofractionated accelerated radiotherapy

被引：22

作者：

Bhide, Shreerang A. ^{[1
,2
]}

Gulliford, Sarah ^{[2
]}

Fowler, Jack ^{[3
,4
]}

Rosenfelder, Nicola ^{[1
]}

Newbold, Katie ^{[1
]}

Harrington, Kevin J. ^{[1
,2
]}

Nutting, Christopher M. ^{[1
,2
]}

机构：

[1] Royal Marsden Hosp, London SW3 6JJ, England

[2] Inst Canc Res, London SW3 6JB, England

[3] Univ Wisconsin, Dept Human Oncol, Madison, WI 53706 USA

[4] Univ Wisconsin, Dept Med Phys, Madison, WI 53706 USA

来源：

RADIOTHERAPY AND ONCOLOGY | 2010年 / 97卷 / 01期

关键词：

Head and neck cancer; Chemo-IMRT; Radiobiology; Hypofractionated; Accelerated; CHEMOTHERAPY; PROLIFERATION; FRACTIONATION; TRIAL;

D O I：

10.1016/j.radonc.2010.08.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Purpose: This study describes the acute response of oral and pharyngeal mucosa to chemo-IMRT schedules using different doses per fraction. Materials and methods: Patients, treated in prospective trials of concomitant chemo-IMRT with 2.17 Gy, 2.25 Gy and 2.4 Gy per fraction and identical dose of cisplatin, were included in this study. Acute toxicity was recorded prospectively using the CTCAE v2.0. We describe the incidence and prevalence of grade 3 oral mucositis and dysphagia over time and report the influence of overall treatment time (OTT). The association between the lengths of pharyngeal mucosa receiving 50 Gy (L50) and 60 Gy (L60) and grade 3 dysphagia was tested. Results: The incidence and the peak prevalence of grade 3 dysphagia were significantly higher in patients receiving 2.4 Gy per fraction. The peak prevalence of grade 3 dysphagia was higher and the recovery was slower in patients with lower OTT (median 38 days vs. 42 days) treatment. There was a significant correlation between L50, L60 and grade 3 dysphagia. A L50 and L60 greater than 8 cm resulted in greater than 60% and 70% incidence of grade 3 dysphagia, respectively. Conclusion: The length of pharyngeal mucosa receiving doses close to the prescription dose correlates with grade 3 dysphagia. It was observed that incidence of grade 3 dysphagia was lower and recovery from it was quicker in patients with greater OTT. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 97 (2010) 86-91

引用

页码：86 / 91

页数：6

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