Occurrence of thyroid autoimmunity in relapsing remitting multiple sclerosis patients undergoing interferon-β treatment

被引：22

作者：

Martinelli, V ^{[1
]}

Gironi, M ^{[1
]}

Rodegher, M ^{[1
]}

Martino, G ^{[1
]}

Comi, G ^{[1
]}

机构：

[1] Univ Milan, San Raffaele Sci Inst, Clin Neurol Unit 4, I-20132 Milan, Italy

来源：

ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1998年 / 19卷 / 02期

关键词：

multiple sclerosis; interferon beta; autoimmunity; thyroiditis;

D O I：

10.1007/BF02427558

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We analyzed the titer of antithyroid autoantibodies (Abs) and thyroid function in 17 multiple sclerosis (MS) patients undergoing interferon-beta (IFN-beta) treatment and in 40 MS control patients. Basal evaluation revealed normal thyroid function in all patients. Abs were detected in 5 IFN-beta-treated patients (29%) and in 4 MS control patients (10%). Our results indicate that IFN-beta treatment may lead to thyroid autoimmunity. We therefore recommend periodic evaluations of antithyroid Abs and thyroid functionality in IFN-beta-treated MS patients.

引用

页码：65 / 67

页数：3

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