Lipidomics applications for disease biomarker discovery in mammal models

被引：11

作者：

Zhao, Ying-Yong ^{[1
]}

Cheng, Xian-Long ^{[2
]}

Lin, Rui-Chao ^{[3
]}

Wei, Feng ^{[2
]}

机构：

[1] Northwest Univ, Coll Life Sci, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, Xian, Shaanxi, Peoples R China

[2] State Food & Drug Adm, Natl Inst Food & Drug Control, Beijing, Peoples R China

[3] Beijing Univ Chinese Med, Sch Chinese Materia Med, Beijing, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2015年 / 9卷 / 02期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

animal models; disease biomarkers; lipid biomarkers; lipidome; lipidomics; lipid profiling; liquid chromatography; mass spectrometry; metabolomics; system biology; PERFORMANCE LIQUID-CHROMATOGRAPHY; CHRONIC-RENAL-FAILURE; CA2+-INDEPENDENT PHOSPHOLIPASE A(2); HUMAN-IMMUNODEFICIENCY-VIRUS; ASSISTED SOXHLET EXTRACTION; MASS-SPECTROMETRIC ANALYSIS; INDUCED INSULIN-RESISTANCE; ALPHA-SYNUCLEIN; SHOTGUN LIPIDOMICS; HEPATIC STEATOSIS;

D O I：

10.2217/BMM.14.81

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Lipidomics is a lipid-targeted metabolomics approach focusing on comprehensive analysis of all lipids with which they interact in biology systems. Recent technological advances in MS and chromatography have greatly enhanced the developments and applications of metabolic profiling of diverse lipids in complex biological samples. Lipidomics will not only provide insights into the specific functions of lipid species in health and disease, but will also identify potential biomarkers for establishing preventive or therapeutic programs for human disease. In this review, recent applications of lipidomics to understand animal models of disease such as metabolic syndromes, neurodegenerative diseases, cancer and infectious diseases are considered. We also discuss the lipidomics for the future perspectives and their potential problems.

引用

页码：153 / 168

页数：16

共 130 条

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