Glycomics Hits the Big Time

被引：571

作者：

Hart, Gerald W. ^{[1
]}

Copeland, Ronald J. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

来源：

CELL | 2010年 / 143卷 / 05期

关键词：

MASS-SPECTROMETRY; PROTEIN GLYCOSYLATION; FUNCTIONAL GLYCOMICS; DISEASE; PHOSPHORYLATION; MICROARRAYS; ANNOTATION; SPECTRA; BINDING; MICE;

D O I：

10.1016/j.cell.2010.11.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cells run on carbohydrates. Glycans, sequences of carbohydrates conjugated to proteins and lipids, are arguably the most abundant and structurally diverse class of molecules in nature. Recent advances in glycomics reveal the scope and scale of their functional roles and their impact on human disease.

引用

页码：672 / 676

页数：5

共 40 条

[1] Determination of glycosylation sites and site-specific heterogeneity in glycoproteins [J].

An, Hyun Joo ;

Froehlich, John W. ;

Lebrilla, Carlito B. .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2009, 13 (04) :421-426

[2] An introduction to bioinformatics for glycomics research [J].

Aoki-Kinoshita, Kiyoko F. .

PLOS COMPUTATIONAL BIOLOGY, 2008, 4 (05)

[3] On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database [J].

Apweiler, R ;

Hermjakob, H ;

Sharon, N .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1999, 1473 (01) :4-8

[4]

Bertozzi C.R., 2009, ESSENTIALS GLYCOBIOL, VSecond

[5] The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics [J].

Cantarel, Brandi L. ;

Coutinho, Pedro M. ;

Rancurel, Corinne ;

Bernard, Thomas ;

Lombard, Vincent ;

Henrissat, Bernard .

NUCLEIC ACIDS RESEARCH, 2009, 37 :D233-D238

[6] GlycoWorkbench: A tool for the computer-assisted annotation of mass spectra of Glycans [J].

Ceroni, Alessio ;

Maass, Kai ;

Geyer, Hildegard ;

Geyer, Rudolf ;

Dell, Anne ;

Haslam, Stuart M. .

JOURNAL OF PROTEOME RESEARCH, 2008, 7 (04) :1650-1659

[7] GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice [J].

Chang, Jungshan ;

Patton, John T. ;

Sarkar, Arun ;

Ernst, Beat ;

Magnani, John L. ;

Frenette, Paul S. .

BLOOD, 2010, 116 (10) :1779-1786

[8] The Sialome-Far More Than the Sum of Its Parts [J].

Cohen, Miriam ;

Varki, Ajit .

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 2010, 14 (04) :455-464

[9] The repertoire of glycan determinants in the human glycome [J].

Cummings, Richard D. .

MOLECULAR BIOSYSTEMS, 2009, 5 (10) :1087-1104

[10] Akira Kobata: a man who established the structural basis for glycobiology of N-linked sugar chains [J].

Endo, Tamao .

JOURNAL OF BIOCHEMISTRY, 2010, 147 (01) :9-17

← 1 2 3 4 →