Kinetics of a drug release from a delayed release device

被引：1

作者：

Bichara, A

Montheard, JP

Taverdet, JL

机构：

[1] Fac Sci & Tech, Lab Chim & Environm, F-42023 St Etienne 2, France

[2] Fac Sci & Tech, Lab Chim Organ Macromol, F-42023 St Etienne 2, France

来源：

EUROPEAN POLYMER JOURNAL | 1998年 / 34卷 / 09期

关键词：

D O I：

10.1016/S0014-3057(97)00264-4

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Reaction of sodium salt of benzoic acid with methacryloyl chloride provides an anhydride which is polymerized by the radical method or copolymerized with various percentages of ethylene glycol dimethacrylate to obtain crosslinked products. Hydrolysis reactions of the resulting polymers were carried out in various aqueous solutions and the rate of release of benzoic acid (simulator of drug) seems to depend both on the percentages of crosslinking comonomer and on the pH of the solution. A model of this delayed release of benzoic acid is also proposed. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1283 / 1293

页数：11

共 14 条

[1] DRUG-RELEASE WITH SIMULTANEOUS DIMENSIONAL CHANGES FROM A NEW COPOLYMERIC HYDROGEL [J].