Demonstration of changes in plasma cell subsets in multiple myeloma

被引：19

作者：

Ayliffe, Michael John ^{[1
]}

Davies, Faith Elizabeth ^{[2
]}

de Castro, David ^{[2
]}

Morgan, Gareth John ^{[2
]}

机构：

[1] St Helier Hosp, Dept Immunol, Wrythe Lane, Carshalton SM3 8NR, Surrey, England

[2] Royal Marsden NHS Fdn Trust, Sect Haematooncol, London, England

来源：

HAEMATOLOGICA | 2007年 / 92卷 / 08期

关键词：

multiple myeloma; bone marrow; plasma cells; free light chains; monoclonal immunoglobulins;

D O I：

10.3324/haematol.11133

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Increases in free light chain (FLC) production are associated with disease progression in multiple myeloma (MM). Using a double immunofluorescence staining method to produce a differential count of plasma cells in bone marrow, single populations were demonstrated, containing intact monoclonal immunoglobulins (M-Igs) in 74% and FLCs only in 8% of cases. However, 18% contained a mixture of both cell populations. Progression from cells making intact M-Ig to cells restricted to FLC only production occurred in individual cases during the course of their disease. The presence of FLC only cells was associated with shortened survival.

引用

页码：1135 / 1138

页数：4

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