Anxiolytic-like effect of succinic acid in mice

被引：42

作者：

Chen, SW ^{[1
]}

Xin, Q ^{[1
]}

Kong, WX ^{[1
]}

Min, L ^{[1
]}

Li, JF ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China

来源：

LIFE SCIENCES | 2003年 / 73卷 / 25期

关键词：

succinic acid; anxiolytic; elevated plus-maze; novel food consumption; hyperthermia; mice;

D O I：

10.1016/j.lfs.2003.06.017

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

The putative anxiolytic activity of succinic acid was examined in male mice by using a number of experimental paradigms of anxiety and compared with that of the known anxiolytic compound diazepam. Use of the elevated plus-maze test revealed that diazepam. (1.0, 2.0 and 4.0 mg/kg, PO) or succinic acid (3.0 or 6.0 mg/kg, PO) increased the percentage of entries into open arms and of time spent on open arms. In novel food consumption test, succinic acid (3.0, 6.0, and 12.0 mg/kg, IP) caused significant increases in food intake during 5 min when compared with the vehicle. In the stress-induced hyperthermia test, 40 min after drug administration rectal temperature was measured, succinic acid at dose of 1.5 mg/kg, inhibited stress-induced hyperthermia. Thus, these findings indicated that, in contrast with diazepam, succinic acid exhibits anxiolytic-like effect. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：3257 / 3264

页数：8

共 24 条

[1]

Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice [J].