Efficient copper (II)-mediated nuclease activity of ortho-quinacridines

被引：45

作者：

Baudoin, O ^{[1
]}

Teulade-Fichou, MP ^{[1
]}

Vigneron, JP ^{[1
]}

Lehn, JM ^{[1
]}

机构：

[1] Coll France, Lab Chim Interact Mol, CNRS, UPR 285, F-75005 Paris, France

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 21期

关键词：

D O I：

10.1039/a806095i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ortho-quinacridine compounds OQ(1) and OQ(2) bind strongly to double stranded DNA and effect efficient cleavage in the presence of Cu2+ and in the absence of reducing agent; their activity increases further in the presence of hydrogen peroxide.

引用

页码：2349 / 2350

页数：2

共 24 条

[1] DESIGN OF A DOUBLE-STRANDED DNA CLEAVING AGENT WITH 2 POLYAMINE METAL-BINDING ARMS - RU(DIP)2MACRON+ [J].

BASILE, LA ;

BARTON, JK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (24) :7548-7550

[2]

Baudoin O, 1998, CHEM-EUR J, V4, P1504, DOI 10.1002/(SICI)1521-3765(19980807)4:8<1504::AID-CHEM1504>3.3.CO

[3]

2-K

[4] Cyclobisintercaland macrocycles: Synthesis and physicochemical properties of macrocyclic polyamines containing two crescent-shaped dibenzophenanthroline subunits [J].

Baudoin, O ;

Teulade-Fichou, MP ;

Vigneron, JP ;

Lehn, JM .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (16) :5458-5470

[5] Copper-mediated nuclease activity of a tambjamine alkaloid [J].

Borah, S ;

Melvin, MS ;

Lindquist, N ;

Manderville, RA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (19) :4557-4562

[6] Oxidative nucleobase modifications leading to strand scission [J].

Burrows, CJ ;

Muller, JG .

CHEMICAL REVIEWS, 1998, 98 (03) :1109-1151

[7] POTENTIAL ANTI-TUMOR AGENTS .28. DEOXYRIBONUCLEIC-ACID POLYINTERCALATING AGENTS [J].

CAIN, BF ;

BAGULEY, BC ;

DENNY, WA .

JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (07) :658-668

[8] HYDROLYSIS OF PHOSPHODIESTERS WITH NI(II), CU(II), ZN(II), PD(II), AND PT(II) COMPLEXES [J].

DEROSCH, MA ;

TROGLER, WC .

INORGANIC CHEMISTRY, 1990, 29 (13) :2409-2416

[9] COPPER(I)-BLEOMYCIN - STRUCTURALLY UNIQUE COMPLEX THAT MEDIATES OXIDATIVE DNA STRAND SCISSION [J].

EHRENFELD, GM ;

RODRIGUEZ, LO ;

HECHT, SM ;

CHANG, C ;

BASUS, VJ ;

OPPENHEIMER, NJ .

BIOCHEMISTRY, 1985, 24 (01) :81-92

[10]

Frau S, 1996, B SOC CHIM FR, V133, P1053

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