New routes for the synthesis of 3-and 5-substituted 2(1H)-pyrazinones

被引：23

作者：

Azzam, R ^{[1
]}

De Borggraeve, W ^{[1
]}

Compernolle, F ^{[1
]}

Hoornaert, GJ ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Organ Synth Lab, B-3001 Heverlee, Belgium

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 09期

关键词：

3-and 5-substituted 2(1H)-pyrazinones; heterocyclic compounds; Suzuki reaction; Heck reaction;

D O I：

10.1016/j.tetlet.2004.01.017

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various 3-(hetero)aryl, 3-alkyl and 3-alkenyl-2(1H)-pyrazinones were prepared by applying the Suzuki and Heck reaction methodology to 3,5-dichloro-2(1H)-pyrazinones. Furthermore, following hydrogenolysis of the 5-chloro substituent and regioselective 5-bromination, this palladium-catalysed cross-coupling approach could be extended to the synthesis of the analogous 5-substituted 2(1H)-pyrazinones. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1885 / 1888

页数：4

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