Process development for the sulfonamide herbicide pyroxsulam

被引：34

作者：

Gonzalez, Michael A. ^{[1
]}

Gorman, David B. ^{[1
]}

Hamilton, Christopher T. ^{[1
]}

Roth, Gary A. ^{[1
]}

机构：

[1] Dow Chem Co USA, Engn & Proc Sci, Midland, MI 48674 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2008年 / 12卷 / 02期

关键词：

D O I：

10.1021/op700281w

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The development of a manufacturing process for the initial commercial production of pyroxsulam sulfonamide herbicide is described. The process encompasses seven reaction steps, and includes a new route to 4-(trifluoromethyl)pyridines, a scaleable method of lithiating a pyridine intermediate, and a sulfilimine-catalyzed formation of a sulfonamide.

引用

页码：301 / 303

页数：3

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