Hybrid chitosan membranes tested in sheep for guided tissue regeneration

被引：4

作者：

Cortez, P. P. ^{[1
,2
]}

Shirosaki, Y. ^{[4
]}

Botelho, C. M. ^{[3
,4
]}

Simoes, M. J. ^{[1
,2
,3
]}

Gartner, F. ^{[2
,5
]}

da Costa, R. M. Gil ^{[2
]}

Tsuru, K. ^{[6
,7
]}

Hayakawa, S. ^{[6
]}

Osaka, A. ^{[6
,7
]}

Lopes, M. A. ^{[3
,4
]}

Santos, J. D. ^{[3
,4
]}

Mauricio, A. C. ^{[1
,2
]}

机构：

[1] Univ Porto, Ctr Estudos Ciencia Anim, ICETA, Campus Agrario Vairao,Rua P Armando quintas, P-4485661 Vairao, Portugal

[2] Univ Porto, Abel Salazar Inst Biomed Ciencias, P-4099003 Oporto, Portugal

[3] Univ Porto, Fac Engenharia, Secao Mat, DEMM, P-4200465 Oporto, Portugal

[4] Inst Engenharia Biomed, Lab Biomat, P-4150180 Oporto, Portugal

[5] Univ Porto, Inst Patol & Molecular Immunol, P-4200465 Oporto, Portugal

[6] Okayama Univ, Grad Sch Nat Sci & Technol, Div Funct Mol Chem, Okayama 7008530, Japan

[7] Okayama Univ, Biomed Engn Res Ctr, Okayama 7008530, Japan

来源：

BIOCERAMICS, VOL 20, PTS 1 AND 2 | 2008年 / 361-363卷

关键词：

guided tissue regeneration (GTR); chitosan; chitosan-silicate hybrid; biodegradable membrane; in vivo study;

D O I：

10.4028/www.scientific.net/KEM.361-363.1265

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 [材料科学与工程]; 080502 [材料学];

摘要：

Previous in vitro studies confirmed an improved cytocompatibility of chitosan-silicate hybrid membranes over chitosan membranes. The main goal of this study was to assess the in vivo histocompatibility of both membranes through subcutaneous implantations at different time periods.. I week, 1, 2 and 3 months, using a sheep model. Chitosan membranes elicited an exuberant inflammatory response and were consequently rejected. The hybrid chitosan membranes were not rejected and the degree of inflammatory response decreased gradually until the third month of implantation. Histological evaluation also showed that these membranes can be resorbed in vivo. This study demonstrates that the incorporation of silicate into the chitosan solution improves its histocompatibility, indicating that the hybrid chitosan-silicate membranes are suitable candidates to be used in clinical applications.

引用

页码：1265 / +

页数：2

共 6 条

[1]

CHITOSAN - AS A BIOMATERIAL [J].

CHANDY, T ;

SHARMA, CP .

BIOMATERIALS ARTIFICIAL CELLS AND ARTIFICIAL ORGANS, 1990, 18 (01) :1-24

[2]

PREPARATION AND CHARACTERIZATION OF FULLY DEACETYLATED CHITOSAN [J].

DOMARD, A ;

RINAUDO, M .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 1983, 5 (01) :49-52

[3]

Guided bone regeneration in the treatment of segmental diaphyseal defects: A comparison between resorbable and non-resorbable membranes [J].

Nasser, NJ ;

Friedman, A ;

Friedman, M ;

Moor, E ;

Mosheiff, R .

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 2005, 36 (12) :1460-1466

[4]

In vitro cytocompatibility of osteoblastic cells cultured on chitosan-organosiloxane hybrid membrane [J].

Shirosaki, Y ;

Tsuru, K ;

Hayakawa, S ;

Osaka, A ;

Lopes, MA ;

Santos, JD ;

Fernandes, MH .

BIOCERAMICS 16, 2004, 254-2 :857-860

[5]

In vitro cytocompatibility of MG63 cells on chitosan-organosiloxane hybrid membranes [J].

Shirosaki, Y ;

Tsuru, K ;

Hayakawa, S ;

Osaka, A ;

Lopes, MA ;

Santos, JD ;

Fernandes, MH .

BIOMATERIALS, 2005, 26 (05) :485-493

[6]

Accelerating effects of chitosan for healing at early phase of experimental open wound in dogs [J].

Ueno, H ;

Yamada, H ;

Tanaka, I ;

Kaba, N ;

Matsuura, M ;

Okumura, M ;

Kadosawa, T ;

Fujinaga, T .

BIOMATERIALS, 1999, 20 (15) :1407-1414

← 1 →