An experimental outer membrane vesicle vaccine from N. meningitidis serogroup B strains that induces serum bactericidal activity to multiple serogroups

被引：26

作者：

Pinto, Valerian B. ^{[1
]}

Moran, Elizabeth E. ^{[1
]}

Cruz, Francisco ^{[2
]}

Wang, Xin-Ming ^{[3
]}

Fridman, Arthur ^{[2
]}

Zollinger, Wendell D. ^{[1
]}

Przysiecki, Craig T. ^{[3
]}

Burden, Robert ^{[1
]}

机构：

[1] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA

[2] Merck Res Labs, IT Informat, Rahway, NJ 07065 USA

[3] Merck Res Labs, Vaccine Basic Res, West Point, PA 19486 USA

来源：

VACCINE | 2011年 / 29卷 / 44期

关键词：

Neisseria meningitidis; Vaccine; Outer membrane vesicles; PNEUMOCOCCAL CONJUGATE VACCINE; NEISSERIA-MENINGITIDIS; WHOLE-CELL; PROTECTIVE IMMUNITY; ESCHERICHIA-COLI; CONTROLLED-TRIAL; PROTEIN; RESPONSES; DISEASE; MICE;

D O I：

10.1016/j.vaccine.2011.07.124

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

A trivalent native outer membrane vesicle vaccine that has potential to provide broad based protection against Neisseria meningitidis serogroup B strains has been developed. Preliminary immunogenicity studies in mice showed that the vaccine was capable of inducing an effective broad based bactericidal antibody response against N. meningitidis serogroup B strains. These findings in mice have been repeated with a cGMP trivalent NOMV vaccine and extended to show that the bactericidal antibody response induced by the vaccine in mice is effective against strains belonging to serogroups C, Y. W135, X. and NadA-expressing serogroup A strains. Taken together these results suggest that this experimental vaccine may provide protection against both serogroup B and non-serogroup B N. meningitidis strains. Published by Elsevier Ltd.

引用

页码：7752 / 7758

页数：7

共 49 条

[1]

Comparison of functional immune responses in humans after intranasal and intramuscular immunisations with outer membrane vesicle vaccines against group B meningococcal disease [J].

Aase, A ;

Næss, LM ;

Sandin, RH ;

Herstad, TK ;

Oftung, F ;

Holst, J ;

Haugen, IL ;

Hoiby, EA ;

Michaelsen, TE .

VACCINE, 2003, 21 (17-18) :2042-2051

[2]

Membrane vesicles are immunogenic facsimiles of Salmonella typhimurium that potently activate dendritic cells, prime B and T cell responses, and stimulate protective immunity in vivo [J].

Alaniz, Robert C. ;

Deatherage, Brooke L. ;

Lara, Jimmie C. ;

Cookson, Brad T. .

JOURNAL OF IMMUNOLOGY, 2007, 179 (11) :7692-7701

[3]

TETRAVALENT MENINGOCOCCAL POLYSACCHARIDE VACCINE GROUPS A, C, Y, W 135 - CLINICAL AND SEROLOGICAL EVALUATION [J].

ARMAND, J ;

ARMINJON, F ;

MYNARD, MC ;

LAFAIX, C .

JOURNAL OF BIOLOGICAL STANDARDIZATION, 1982, 10 (04) :335-339

[4]

Outer membrane vesicles obtained from Bordetella pertussis Tohama expressing the lipid A deacylase PagL as a novel acellular vaccine candidate [J].

Asensio, Cristian J. A. ;

Emilia Gaillard, Maria ;

Moreno, Griselda ;

Bottero, Daniela ;

Zurita, Eugenia ;

Rumbo, Martin ;

van der Ley, Peter ;

van der Ark, Arno ;

Hozbor, Daniela .

VACCINE, 2011, 29 (08) :1649-1656

[5]

Meningococcal outer membrane vesicle vaccine given intranasally can induce immunological memory and booster responses without evidence of tolerance [J].

Bakke, H ;

Lie, K ;

Haugen, IL ;

Korsvold, GE ;

Hoiby, EA ;

Næss, LM ;

Holst, J ;

Aaberge, IS ;

Oftung, F ;

Haneberg, B .

INFECTION AND IMMUNITY, 2001, 69 (08) :5010-5015

[6]

Meningococcal Factor H-Binding Protein Variants Expressed by Epidemic Capsular Group A, W-135, and X Strains from Africa [J].

Beernink, P. T. ;

Caugant, D. A. ;

Welsch, J. A. ;

Koeberling, O. ;

Granoff, D. M. .

JOURNAL OF INFECTIOUS DISEASES, 2009, 199 (09) :1360-1368

[7]

EFFECT OF OUTER-MEMBRANE VESICLE VACCINE AGAINST GROUP-B MENINGOCOCCAL DISEASE IN NORWAY [J].

BJUNE, G ;

HOIBY, EA ;

GRONNESBY, JK ;

ARNESEN, O ;

HOLSTFREDRIKSEN, J ;

HALSTENSEN, A ;

HOLTEN, E ;

LINDBAK, AK ;

NOKLEBY, H ;

ROSENQVIST, E ;

SOLBERG, LK ;

CLOSS, O ;

ENG, J ;

FROHOLM, LO ;

LYSTAD, A ;

BAKKETEIG, LS ;

HAREIDE, B .

LANCET, 1991, 338 (8775) :1093-1096

[8]

Three Doses of an Experimental Detoxified L3-Derived Lipooligosaccharide Meningococcal Vaccine Offer Good Safety but Low Immunogenicity in Healthy Young Adults [J].

Bonvehi, Pablo ;

Boutriau, Dominique ;

Casellas, Javier ;

Weynants, Vincent ;

Feron, Christiane ;

Poolman, Jan .

CLINICAL AND VACCINE IMMUNOLOGY, 2010, 17 (09) :1460-1466

[9]

EFFICACY, SAFETY, AND IMMUNOGENICITY OF A MENINGOCOCCAL GROUP-B (15-P1.3) OUTER-MEMBRANE PROTEIN VACCINE IN IQUIQUE, CHILE [J].

BOSLEGO, J ;

GARCIA, J ;

CRUZ, C ;

ZOLLINGER, W ;

BRANDT, B ;

RUIZ, S ;

MARTINEZ, M ;

ARTHUR, J ;

UNDERWOOD, P ;

SILVA, W ;

MORAN, E ;

HANKINS, W ;

GILLY, J ;

MAYS, J .

VACCINE, 1995, 13 (09) :821-829

[10]

Chemistry of a new investigational quadrivalent meningococcal conjugate vaccine that is immunogenic at all ages [J].

Broeker, Michael ;

Dull, Peter M. ;

Rappuoli, Rino ;

Costantino, Paolo .

VACCINE, 2009, 27 (41) :5574-5580

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