Phase II Trial of Preoperative Chemotherapy with Docetaxel, Cisplatin and S-1 for T4 Locally Advanced Gastric Cancer

被引：8

作者：

Fushida, Sachio ^{[1
]}

Nashimoto, Atsushi ^{[2
]}

Fukushima, Norimasa ^{[3
]}

Kawachi, Yasuyuki ^{[4
]}

Fujimura, Takashi ^{[1
]}

Kuwabara, Shiro ^{[6
]}

Musha, Nobuyuki ^{[5
]}

机构：

[1] Kanazawa Univ Hosp, Dept Surg Gastroenterol, Kanazawa, Ishikawa 9208641, Japan

[2] Niigata Canc Ctr Hosp, Dept Surg, Niigata, Japan

[3] Yamagata Prefectural Cent Hosp, Dept Surg, Yamagata, Japan

[4] Nagaoka Chuo Gen Hosp, Dept Surg, Nagaoka, Niigata, Japan

[5] Saiseikai Niigata Daini Hosp, Dept Surg, Saiseikai, Japan

[6] Niigata City Gen Hosp, Dept Surg, Niigata, Japan

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 2012年 / 42卷 / 02期

关键词：

FEASIBILITY;

D O I：

10.1093/jjco/hyr183

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The standard treatment for T4 locally advanced gastric cancer is gastrectomy with D2 lymph node dissection followed by adjuvant chemotherapy with S-1 for 12 months; however, prognostic outcome in Stage IIIb has been insufficient. It is expected that survival is improved by preoperative treatment with a triplet regimen of docetaxel, cisplatin and S-1 (divided DCS therapy). A multicenter Phase II study has been conducted to evaluate the safety and efficacy of two courses of preoperative chemotherapy followed by gastrectomy. Fifty-five patients are required for this study. The primary endpoint of the study is pathological response rate of primary lesions. Secondary endpoints are overall survival, disease-free survival, R0 resection rate and adverse events.

引用

页码：131 / 133

页数：3

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