Inflammatory mediators in patients receiving long-term home parenteral nutrition

被引：22

作者：

Ling, PR ^{[1
]}

Khaodhiar, L ^{[1
]}

Bistrian, BR ^{[1
]}

Keane-Ellison, M ^{[1
]}

Thibault, A ^{[1
]}

Tawa, N ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Lab Nutr Infect, Boston, MA 02215 USA

来源：

DIGESTIVE DISEASES AND SCIENCES | 2001年 / 46卷 / 11期

关键词：

home total parenteral nutrition; albumin; C-reactive protein; interleukin; 6; soluble tumor necrosis factor receptor II;

D O I：

10.1023/A:1012388206553

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This study was designed to examine circulating and urine cytokine levels in patients receiving long-term home total parenteral nutrition (TPN) support. Twelve patients who had been receiving home TPN for more than 1 year (range, 1.3-19.5 years) were enrolled for study. To avoid the potential confounding effects of intercurrent infection, patients were studied during periods of clinical stability without clinical evidence of infection. Ten normal healthy volunteers served as controls. Serum levels of albumin and C-reactive protein, temperature, body weight, and blood white cell counts were determined. The levels of soluble tumor necrosis factor receptor II (sTNF-RII) and interleukin 6 (IL-6) were measured in serum and 24-hr urine. The results showed that the concentrations of sTNF-RII and IL-6 in 24-hr urine and serum were significantly higher in patients, indicating that long-term home TPN may be associated with a persistent low-grade inflammatory state.

引用

页码：2484 / 2489

页数：6

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