The bacteriocin nisin, an effective agent for the treatment of staphylococcal mastitis during lactation

被引:82
作者
Fernandez, Leonides [1 ]
Delgado, Susana
Herrero, Helena [2 ,3 ]
Maldonado, Antonio
Rodriguez, Juan M.
机构
[1] Univ Complutense Madrid, Dept Nutr Bromatol & Tecnol Alimentos, E-28040 Madrid, Spain
[2] Hosp San Agustin, Aviles, Spain
[3] Assoc Amamantar, Aviles, Spain
关键词
nisin; mastitis; Staphylococcus; lactation;
D O I
10.1177/0890334408317435
中图分类号
R47 [护理学];
学科分类号
1011 ;
摘要
Eight women with clinical signs of staphylococcal mastitis were randomly divided in 2 groups. A solution of the bacteriocin nisin (6 tg/mQ was applied to the nipple and mammary areola of those assigned to the nisin group for 2 weeks, and a similar preparation devoid of nisin was applied to the control group. On day 0, staphylococcal counts in breast milk of the nisin and control groups were similar (5.04 0.19 and 4.88 0.21 log,0 CFU/mL, respectively). However, on day 14, the mean in the nisin group (3.22 0.43 log,, CFU/mL) was statistically lower than that of the control group (5.01 0.21 log,0 CFU/mL). No clinical signs of mastitis were observed among the women of the nisin group on day 14, whereas they persisted throughout the study in the women of the control group. In conclusion, nisin seems to be an efficient alternative to antibiotics for the treatment of staphylococcal mastitis.
引用
收藏
页码:311 / 316
页数:6
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