Serum antibody as a marker of protection against natural rotavirus infection and disease

被引:148
作者
Velázquez, FR
Matson, DO
Guerrero, ML
Shults, J
Calva, JJ
Morrow, AL
Glass, RI
Pickering, LK
Ruiz-Palacios, GM
机构
[1] Inst Nacl Nutr Salvador Zubiran, Dept Infect Dis, Mexico City 14000, DF, Mexico
[2] Childrens Hosp Kings Daughters, Ctr Pediat Res, Norfolk, VA USA
[3] Eastern Virginia Med Sch, Norfolk, VA 23501 USA
[4] Ctr Dis Control & Prevent, Viral Gastroenteritis Unit, Atlanta, GA 30341 USA
关键词
D O I
10.1086/317619
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To determine whether naturally acquired serum IgA and IgG antibodies were associated with protection against rotavirus infection and illness, a cohort of 200 Mexican infants was monitored weekly for rotavirus excretion and diarrhea from birth to age 2 years. Serum samples collected during the first week after birth and every 4 months were tested for antirotavirus IgA and IgG. Children with an IgA titer >1:800 had a lower risk of rotavirus infection (adjusted relative risk [aRR], 0.21; P < .001) and diarrhea (aRR, 0.16; P = .01) and were protected completely against moderate-to-severe diarrhea, However, children with an IgG titer >1:6400 were protected against rotavirus infection (aRR, 0.51; P <, .001) but not against rotavirus diarrhea. Protective antibody titers were achieved after 2 consecutive symptomatic or asymptomatic rotavirus infections. These findings indicate that serum anti-rotavirus antibody, especially IgA, was a marker of protection against rotavirus infection and moderate-to-severe diarrhea.
引用
收藏
页码:1602 / 1609
页数:8
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