Adherens junctions: from molecules to morphogenesis

被引：596

作者：

Harris, Tony J. C. ^{[1
]}

Tepass, Ulrich ^{[1
]}

机构：

[1] Univ Toronto, Dept Cell & Syst Biol, Toronto, ON M5S 3G5, Canada

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2010年 / 11卷 / 07期

基金：

加拿大健康研究院;

关键词：

CELL-CELL ADHESION; CLATHRIN-DEPENDENT ENDOCYTOSIS; CADHERIN-MEDIATED ADHESION; EXCHANGE FACTOR TIAM1; BETA-CATENIN; ALPHA-CATENIN; EPITHELIAL-CELLS; P120; CATENIN; VE-CADHERIN; DROSOPHILA GASTRULATION;

D O I：

10.1038/nrm2927

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

How adhesive interactions between cells generate and maintain animal tissue structure remains one of the most challenging and long-standing questions in cell and developmental biology. Adherens junctions (AJs) and the cadherin-catenin complexes at their core are therefore the subjects of intense research. Recent work has greatly advanced our understanding of the molecular organization of AJs and how cadherin-catenin complexes engage actin, microtubules and the endocytic machinery. As a result, we have gained important insights into the molecular mechanisms of tissue morphogenesis.

引用

页码：502 / 514

页数：13

共 169 条

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