Discovery and development of biomarkers of neurological disease

被引：60

作者：

Dunckley, T ^{[1
]}

Coon, KD ^{[1
]}

Stephan, DA ^{[1
]}

机构：

[1] Translat Genom Res Inst, Neurogenom Div, Phoenix, AZ 85004 USA

来源：

DRUG DISCOVERY TODAY | 2005年 / 10卷 / 05期

关键词：

D O I：

10.1016/S1359-6446(04)03353-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The identification of clinically relevant biomarkers for neurological diseases poses unique challenges. These include an historical lack of availability of relevant tissues from the site of pathology, relatively poorly matured techniques for disease diagnosis, the complexity and cellular heterogeneity of the brain, and a clear deficiency of models for functional validation of candidate biomarkers. Here, the unique challenges that neurological disorders introduce to biomarker discovery are described and how modern technological advances in genomics, proteornics and metabolomics are overcoming these obstacles and are driving the discovery of novel biomarkers to improve early diagnosis and therapeutic treatment is discussed.

引用

页码：326 / 334

页数：9

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