Real-time, step-wise, electrical detection of protein molecules using dielectrophoretically aligned SWNT-film FET aptasensors

被引：33

作者：

An, Taechang ^{[2
]}

Kim, Ki Su ^{[1
]}

Hahn, Sei Kwang ^{[1
]}

Lim, Geunbae ^{[2
,3
]}

机构：

[1] Pohang Univ Sci & Technol POSTECH, Dept Mat Sci & Engn, Pohang 790784, Kyungbuk, South Korea

[2] Pohang Univ Sci & Technol POSTECH, Dept Mech Engn, Pohang 790784, Kyungbuk, South Korea

[3] Pohang Univ Sci & Technol POSTECH, Dept Integrat Biosci & Biotechnol, Pohang 790784, Kyungbuk, South Korea

来源：

LAB ON A CHIP | 2010年 / 10卷 / 16期

关键词：

CARBON NANOTUBES; DNA; APTAMERS;

D O I：

10.1039/c005276k

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Aptamer functionalized addressable SWNT-film arrays between cantilever electrodes were successfully developed for biosensor applications. Dielectrophoretically aligned SWNT suspended films made possible highly specific and rapid detection of target proteins with a large binding surface area. Thrombin aptamer immobilized SWNT-film FET biosensor resulted in a real-time, label-free, and electrical detection of thrombin molecules down to a concentration of ca. 7 pM with a step-wise rapid response time of several seconds.

引用

页码：2052 / 2056

页数：5

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