Increase in activin beta A mRNA in rat hippocampus during long-term potentiation

被引：79

作者：

Inokuchi, K ^{[1
]}

Kato, A ^{[1
]}

Hiraia, K ^{[1
]}

Hishinuma, F ^{[1
]}

Inoue, M ^{[1
]}

Ozawa, F ^{[1
]}

机构：

[1] AZABU UNIV,DEPT PHYSIOL 2,SAGAMIHARA,KANAGAWA 229,JAPAN

来源：

FEBS LETTERS | 1996年 / 382卷 / 1-2期

关键词：

mRNA differential display; long-term potentiation; seizure; TGF-beta superfamily; activin; synaptic plasticity;

D O I：

10.1016/0014-5793(96)00135-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have used mRNA differential display to isolate genes that are induced by neural activity in rat hippocampus. One of these encodes activin beta A subunit. Convulsive seizure caused by kainate significantly induced the expression of activin beta A mRNA, Furthermore high frequency stimulation (HFS) of perforant pathway, which produced a persistent long-term potentiation (LTP) (>10 h), caused a marked increase at 3 h in the level of activin beta A mRNA at the dentate gyrus of urethane-anesthetized rat, The increase was NMDA receptor-dependent. By contrast the level of inhibin alpha mRNA was not changed following the induction of LTP. The results suggest a role for activin in maintenance of neural plasticity in the adult brain.

引用

页码：48 / 52

页数：5

共 38 条

[1] CORRELATIONS BETWEEN IMMEDIATE-EARLY GENE INDUCTION AND THE PERSISTENCE OF LONG-TERM POTENTIATION [J].

ABRAHAM, WC ;

MASON, SE ;

DEMMER, J ;

WILLIAMS, JM ;

RICHARDSON, CL ;

TATE, WP ;

LAWLOR, PA ;

DRAGUNOW, M .

NEUROSCIENCE, 1993, 56 (03) :717-727

[2] A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].

BLISS, TVP ;

COLLINGRIDGE, GL .

NATURE, 1993, 361 (6407) :31-39

[3] HYBRIDIZATION HISTOCHEMICAL-LOCALIZATION OF ACTIVIN RECEPTOR SUBTYPES IN RAT-BRAIN, PITUITARY, OVARY, AND TESTIS [J].

CAMERON, VA ;

NISHIMURA, E ;

MATHEWS, LS ;

LEWIS, KA ;

SAWCHENKO, PE ;

VALE, WW .

ENDOCRINOLOGY, 1994, 134 (02) :799-808

[4] TRANSCRIPTION OF THE DYSTROPHIN GENE IN HUMAN-MUSCLE AND NON-MUSCLE TISSUES [J].

CHELLY, J ;

KAPLAN, JC ;

MAIRE, P ;

GAUTRON, S ;

KAHN, A .

NATURE, 1988, 333 (6176) :858-860

[5] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].

CHIRGWIN, JM ;

PRZYBYLA, AE ;

MACDONALD, RJ ;

RUTTER, WJ .

BIOCHEMISTRY, 1979, 18 (24) :5294-5299

[6] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].

CHOMCZYNSKI, P ;

SACCHI, N .

ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) :156-159

[7] RAPID INCREASE OF AN IMMEDIATE EARLY GENE MESSENGER-RNA IN HIPPOCAMPAL-NEURONS BY SYNAPTIC NMDA RECEPTOR ACTIVATION [J].

COLE, AJ ;

SAFFEN, DW ;

BARABAN, JM ;

WORLEY, PF .

NATURE, 1989, 340 (6233) :474-476

[8] PROTEIN-SYNTHESIS AND MEMORY - A REVIEW [J].

DAVIS, HP ;

SQUIRE, LR .

PSYCHOLOGICAL BULLETIN, 1984, 96 (03) :518-559

[9] ANISOMYCIN, AN INHIBITOR OF PROTEIN-SYNTHESIS, BLOCKS LATE PHASES OF LTP PHENOMENA IN THE HIPPOCAMPAL CA1 REGION INVITRO [J].

FREY, U ;

KRUG, M ;

REYMANN, KG ;

MATTHIES, H .

BRAIN RESEARCH, 1988, 452 (1-2) :57-65

[10] EFFECTS OF CAMP SIMULATE A LATE-STAGE OF LTP IN HIPPOCAMPAL CA1 NEURONS [J].

FREY, U ;

HUANG, YY ;

KANDEL, ER .

SCIENCE, 1993, 260 (5114) :1661-1664

← 1 2 3 4 →