Radiation effects on neural precursor cells in the dentate gyrus

被引：64

作者：

Andres-Mach, Marta ^{[1
,5
]}

Rola, Radoslaw ^{[1
,4
,5
]}

Fike, John R. ^{[1
,2
,3
]}

机构：

[1] San Francisco Gen Hosp, Dept Neurol Surg, San Francisco, CA 94110 USA

[2] Univ Calif San Francisco, Dept Radiat Oncol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA

[4] F Skubiszewski Med Univ, Dept Neurol Surg, Lublin, Poland

[5] Inst Agr Med, Dept Physiopathol, Lublin, Poland

来源：

CELL AND TISSUE RESEARCH | 2008年 / 331卷 / 01期

关键词：

radiation; brain; neurogenesis; stem cell; neural precursor;

D O I：

10.1007/s00441-007-0480-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ionizing irradiation is an effective treatment for intracranial tumors but is limited by the potential adverse effects induced in surrounding normal brain. These effects can include cognitive impairments, and whereas the pathogenesis of such injury has not yet been definitively established, it may involve injury to the neurogenic cell population that exists in the dentate subgranular zone (SGZ) of the hippocampus. Understanding the issues surrounding this topic could have a major impact in the management of specific sequelae associated with cranial irradiation. Although radiation is now becoming a useful tool in investigations into the biology of neurogenesis, the perspective of this review is directed more toward the potential relevance of studying radiation and the stem/precursor cell response.

引用

页码：251 / 262

页数：12

共 108 条

[1] Pathogenesis of irradiation-induced cognitive dysfunction [J].