Integrin characterization in pulmonary bronchioles

被引：4

作者：

Blundell, RA ^{[1
]}

Harrison, DJ

机构：

[1] Univ Malta, Dept Physiol & Biochem, Msida, Malta

[2] Univ Edinburgh, Sch Med, Dept Pathol, Edinburgh EH8 9AG, Midlothian, Scotland

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2005年 / 79卷 / 01期

关键词：

Clara cells; integrin; pulmonary bronchioles;

D O I：

10.1016/j.yexmp.2005.04.004

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Integrins are a family of cell surface glycoproteins that act as receptors for ECM proteins or for membrane bound counter-receptors on other cells. The integrin receptor family of vertebrates includes at least 16 distinct alpha subunits and at least 8 beta subunits which can associate to form more than 20 distinct integrins. So far, there are no published reports describing integrin characterization in mouse lung tissue and mouse Clara cells. This paper described the characterization of six integrins, mainly alpha(5), alpha(v), alpha(6), beta(1), beta(3), and beta(4), in mouse pulmonary bronchioles and also in Clara cell cultures. alpha(5), alpha(v), alpha(6), beta(1), and beta(4) integrins were present in Clara cells both in tissue sections and cultures. beta(3) integrin was found to be absent in mouse Clara cells. (C) 2005 Elsevier Inc. All rights reserved.

引用

页码：74 / 78

页数：5

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