Urinary detection of podocyte injury

被引：50

作者：

Camici, Marcello ^{[1
]}

机构：

[1] Univ Pisa, Dept Internal Med, I-56126 Pisa, Italy

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2007年 / 61卷 / 05期

关键词：

glomerular disease; podocyte dysfunction; urinary podocyte; GLOMERULAR PROTEIN; NEPHROTIC SYNDROME; DISEASE-ACTIVITY; SLIT DIAPHRAGM; NEPHRIN; EXPRESSION; GLOMERULOSCLEROSIS; PODOCALYXIN; GENE; TRANSDIFFERENTIATION;

D O I：

10.1016/j.biopha.2006.12.009

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Glomerular epithelial cell (podocyte) biology has been focused on in the last few years. The emerging understanding in podocyte biology has improved the molecular mechanism knowledge in many glomerular diseases. Urinary podocyte count and measurement of urinary podocyte specific markers (nephrin and podocalyxin) have been developed to detect podocyte injury. We discuss the emerging clinical importance of the urinary podocyte count in experimental and human glomerular disease, as well as measurement of urinary podocyte specific marker. (c) 2007 Published by Elsevier Masson SAS.

引用

页码：245 / 249

页数：5

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