Evaluation of autophagy using mouse models of brain injury

被引：17

作者：

Au, Alicia K. ^{[1
]}

Bayir, Huelya ^{[1
,2
]}

Kochanek, Patrick M. ^{[1
,3
]}

Clark, Robert S. B. ^{[1
,3
]}

机构：

[1] Brain Trauma Res Ctr, Safar Ctr Resuscitat Res, Dept Crit Care Med, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Environm & Occupat Hlth, Pittsburgh, PA 15261 USA

[3] Univ Pittsburgh, Sch Med, Dept Pediat, Childrens Hosp Pittsburgh,UPMC, Pittsburgh, PA 15261 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2010年 / 1802卷 / 10期

关键词：

Autophagosome; Controlled cortical impact; Hypoxia ischemia; Mitophagy; Traumatic brain injury; CELL-DEATH; HYPOXIA-ISCHEMIA; MONITORING AUTOPHAGY; NEURONAL APOPTOSIS; CEREBRAL-ISCHEMIA; PROTEIN-SYNTHESIS; MICE; STRESS; INHIBITOR; DISEASE;

D O I：

10.1016/j.bbadis.2009.10.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Autophagy is a homeostatic, carefully regulated, and dynamic process for intracellular recycling of bulk proteins, aging organelles, and lipids. Autophagy occurs in all tissues and cell types, including the brain and neurons. Alteration in the dynamics of autophagy has been observed in many diseases of the central nervous system. Disruption of autophagy for an extended period of time results in accumulation of unwanted proteins and neurodegeneration. However, the role of enhanced autophagy after acute brain injury remains undefined. Established mouse models of brain injury will be valuable in clarifying the role of autophagy after brain injury and are the topic of discussion in this review. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：918 / 923

页数：6

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