Cooperation of translocase complexes in mitochondrial protein import

被引：66

作者：

Kutik, Stephan

Guiard, Bernard

Meyer, Helmut E.

Wiedemann, Nils

Pfanner, Nikolaus ^{[1
]}

机构：

[1] Univ Freiburg, Zentrum Biochem & Mol Zellforschung, Inst Biochem & Molbiol, D-79104 Freiburg, Germany

[2] Univ Freiburg, Fac Biol, D-79104 Freiburg, Germany

[3] CNRS, Ctr Genet Mol, F-91190 Gif Sur Yvette, France

[4] Ruhr Univ Bochum, Med Prot Ctr, D-44780 Bochum, Germany

来源：

JOURNAL OF CELL BIOLOGY | 2007年 / 179卷 / 04期

关键词：

D O I：

10.1083/jcb.200708199

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Most mitochondrial proteins are synthesized in the cytosol and imported into one of the four mitochondrial compartments: outer membrane, intermembrane space, inner membrane, and matrix. Each compartment contains protein complexes that interact with precursor proteins and promote their transport. These translocase complexes do not act as independent units but cooperate with each other and further membrane complexes in a dynamic manner. We propose that a regulated coupling of translocases is important for the coordination of preprotein translocation and efficient sorting to intramitochondrial compartments.

引用

收藏

页码：585 / 591

页数：7

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