IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

被引：994

作者：

Aujla, Shean J. ^{[1
]}

Chan, Yvonne R. ^{[2
]}

Zheng, Mingquan ^{[1
]}

Fei, Mingjian ^{[1
]}

Askew, David J. ^{[3
,4
]}

Pociask, Derek A. ^{[1
]}

Reinhart, Todd A. ^{[5
]}

McAllister, Florencia ^{[1
]}

Edeal, Jennifer ^{[1
]}

Gaus, Kristi ^{[5
]}

Husain, Shahid ^{[6
]}

Kreindler, James L. ^{[1
]}

Dubin, Patricia J. ^{[1
]}

Pilewski, Joseph M. ^{[2
]}

Myerburg, Mike M. ^{[2
]}

Mason, Carol A. ^{[7
]}

Iwakura, Yoichiro ^{[8
]}

Kolls, Jay K. ^{[1
]}

机构：

[1] Childrens Hosp Pittsburgh, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Med Ctr, Newborn Med Program, Childrens Hosp Pittsburgh, Pittsburgh, PA 15213 USA

[4] Magee Womens Res Inst, Pittsburgh, PA 15213 USA

[5] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Infect Dis & Microbiol, Pittsburgh, PA 15261 USA

[6] Univ Pittsburgh, Med Ctr, Div Infect Dis, Transplant Infect Dis Unit, Pittsburgh, PA 15213 USA

[7] Louisiana Hlth Sci Ctr, Div Pulm & Crit Care Med, New Orleans, LA 70112 USA

[8] Univ Tokyo, Ctr Med Expt, Inst Med Sci, Minato Ku, Tokyo 1088639, Japan

来源：

NATURE MEDICINE | 2008年 / 14卷 / 03期

关键词：

D O I：

10.1038/nm1710

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Emerging evidence supports the concept that T helper type 17 (T(H)17) cells, in addition to mediating autoimmunity, have key roles in mucosal immunity against extracellular pathogens. Interleukin-22 (IL-22) and IL-17A are both effector cytokines produced by the T(H)17 lineage, and both were crucial for maintaining local control of the Gram-negative pulmonary pathogen, Klebsiella pneumoniae. Although both cytokines regulated CXC chemokines and granulocyte colony-stimulating factor production in the lung, only IL-22 increased lung epithelial cell proliferation and increased transepithelial resistance to injury. These data support the concept that the T(H)17 cell lineage and its effector molecules have evolved to effect host defense against extracellular pathogens at mucosal sites.

引用

页码：275 / 281

页数：7

共 40 条

[1]

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells [J].

Acosta-Rodriguez, Eva V. ;

Napolitani, Giorgio ;

Lanzavecchia, Antonio ;

Sallusto, Federica .

NATURE IMMUNOLOGY, 2007, 8 (09) :942-949

[2]

Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells [J].

Acosta-Rodriguez, Eva V. ;

Rivino, Laura ;

Geginat, Jens ;

Jarrossay, David ;

Gattorno, Marco ;

Lanzavecchia, Antonio ;

Sallusto, Federica ;

Napolitani, Giorgio .

NATURE IMMUNOLOGY, 2007, 8 (06) :639-646

[3]

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells [J].

Batten, Marcel ;

Li, Ji ;

Yi, Sothy ;

Kljavin, Noelyn M. ;

Danilenko, Dimitry M. ;

Lucas, Sophie ;

Lee, James ;

de Sauvage, Frederic J. ;

Ghilardi, Nico .

NATURE IMMUNOLOGY, 2006, 7 (09) :929-936

[4]

Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury [J].

Berger, T ;

Togawa, A ;

Duncan, GS ;

Elia, AJ ;

You-Ten, A ;

Wakeham, A ;

Fong, HEH ;

Cheung, CC ;

Mak, TW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (06) :1834-1839

[5]

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells [J].

Bettelli, E ;

Carrier, YJ ;

Gao, WD ;

Korn, T ;

Strom, TB ;

Oukka, M ;

Weiner, HL ;

Kuchroo, VK .

NATURE, 2006, 441 (7090) :235-238

[6]

Pneumonia in the solid organ transplant patient [J].

Chakinala, MM ;

Trulock, EP .

CLINICS IN CHEST MEDICINE, 2005, 26 (01) :113-+

[7]

CD4+T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism [J].

Chung, DR ;

Kasper, DL ;

Panzo, RJ ;

Chtinis, T ;

Grusby, MJ ;

Sayegh, MH ;

Tzianabos, AO .

JOURNAL OF IMMUNOLOGY, 2003, 170 (04) :1958-1963

[8]

Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9 [J].

Dumoutier, L ;

Louahed, J ;

Renauld, JC .

JOURNAL OF IMMUNOLOGY, 2000, 164 (04) :1814-1819

[9]

Improved detection of simian immunodeficiency virus RNA by in situ hybridization in fixed tissue sections: combined effects of temperatures for tissue fixation and probe hybridization [J].

Fallert, BA ;

Reinhart, TA .

JOURNAL OF VIROLOGICAL METHODS, 2002, 99 (1-2) :23-32

[10]

Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron [J].

Flo, TH ;

Smith, KD ;

Sato, S ;

Rodriguez, DJ ;

Holmes, MA ;

Strong, RK ;

Akira, S ;

Aderem, A .

NATURE, 2004, 432 (7019) :917-921

← 1 2 3 4 →